Mood disorders are devastating, often chronic illnesses characterized by low mood, poor affect, and anhedonia.\nNotably, mood disorders are approximately twice as prevalent in women compared to men. If sex differences in\nmood are due to underlying biological sex differences, a better understanding of the biology is warranted to\ndevelop better treatment or even prevention of these debilitating disorders. In this review, our goals are to:\n1) summarize the literature related to mood disorders with respect to sex differences in prevalence, 2) introduce\nthe corticolimbic brain network of mood regulation, 3) discuss strategies and challenges of modeling mood\ndisorders in mice, 4) discuss mechanisms underlying sex differences and how these can be tested in mice, and\n5) discuss how our group and others have used a translational approach to investigate mechanisms underlying\nsex differences in mood disorders in humans and mice.
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