Objective: Brain Metastasis (BM) from primary gynecologic cancers is a rare entity. The advances\nand successes in the treatment of primary gynecologic malignancies, have led to prolonged survival\nand, a higher incidence of BM. This study aims to report the experience at our institution in\nmanaging these patients, and provide possible data points that may be essential to note as prognostic\nfactors, and see if our findings are consistent with the literature in this subject. We also aim\nto provide a brief literature review of patients with gynecologic cancers and BM. Methods: This is a\nsmall single institution retrospective study of 23 patients with a gynecologic malignancy and BM,\nidentified between the years 2007-2015. Data were collected on variables including patient demographics,\ndisease and treatment. Results: The median overall survival from the primary diagnosis\nwas 28 months. Median time from diagnosis of BM to death was 9 months. Conclusion: The\noutcomes in our study are similar to what is stated in the current literature with regard to BM\nfrom gynecologic malignancies. Our literature search also revealed that the molecular analysis\nand treatment of the primary tumor remain important to prevent BMs. The tendency of tumors to\nmetastasize varies for one tumor type to another for the same type of tumor. The tendency to develop\nBM may not only depend on risk factors such as stage, grade, and histology, but also on the\ngenetic profile of the primary tumor. The study suggests that multimodal treatment of BM has\nbetter outcomes in managing BM from gynecologic cancers.
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