A retrospective descriptive study is conducted at the San Juan de Dios Hospital,\nSan José, Costa Rica, during the period from February 2016 to March\n2017, with a total of 37 patients from which a combined screening during the\nfirst trimester of pregnancy was conducted, evaluating maternal age, biochemical\nand sonographic methods that together can predict the risk of fetal\nchromosomal alterations during pregnancy. The purpose of using combined\nscreening as a noninvasive method is to identify high risk gestations and to\nminimize the number of invasive procedures to detect the highest number of\ncases. Four patients with higher risk of aneuploidy during pregnancy were\nidentified through this screening.
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