Objective. The relationship between serum progesterone and the first trimester pregnancy outcome of threatened abortion is still\ncontroversial. Therefore, we aimed to further study the association between these two parameters. Methods. The present study is\nan observational retrospective cohort study. A total of 726 participants who had threatened abortion from a hospital in\nGuangdong, China, were included in this study from 17th August 2011 to 30th October 2018. The exposure variable and the\noutcome variable were serum progesterone measured at baseline and early pregnancy outcome, respectively. Covariates involved\nin this study included patientsâ?? basic demographics, obstetric history, and clinical information. Results. A negative association\nand a saturation effect were detected between serum progesterone and the first trimester pregnancy outcome. When\nprogesterone <90.62 nmol/L, an increase in 1 nmol/L of serum progesterone was associated with 3% decrease of the risk of\nmiscarriage (OR: 0.97, 95% CI: 0.95-0.98). Conclusion. There was a greater risk of abortion when the serum progesterone level\nwas less than 90.62 nmol/L. Our findings can better assist the clinician in understanding patientsâ?? conditions and making\nmedical decisions.
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