Voltage-gated sodium channels (NaV) play a crucial role in development and propagation of action potentials in neurons and muscle\ncells. NaV1.7 channels take a special place in modern science since it is believed that they contribute to nerve hyper excitability.\nMutations of the gene SCN9A, which codes the ???? subunit of NaV1.7 channels, are associated with pain perception disorders\n(primary erythermalgia, congenital analgesia, and paroxysmal pain disorder). It is considered that the SCN9A gene mutations\nmay cause variations in sensitivity to pain, from complete insensitivity to extreme sensitivity. Further research of the SCN9A gene\npolymorphism influence on pain sensitivity is essential for the understanding of the pathophysiology of pain and the development\nof the appropriate targeted pain treatment.
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