The aim of this study is to compare the efficacy and safety of propofol with dexmedetomidine in patients with obstructive sleep\napnea hypopnea syndrome (SAHS) undergoing drug-induced sleep endoscopy (DISE). The 88 patients diagnosed with SAHS\nin the Affiliated Hospital of Xuzhou Medical University were randomly allocated into 2 groups (n = 44). Patients in the group\ndexmedetomidine (group D) received continuous intravenous infusion of dexmedetomidine 1----g/kg over 15 minutes before the\nendoscopy, and propofol 2 mg/kg was intravenously administrated in the group propofol (group P). Cardiopulmonary parameters\nof patients were recorded.The time to fall asleep, duration of endoscopic examination, the wakeup time of patients, the number of\nmask ventilations for patients, the satisfaction of patients and endoscopic performers, and false positive cases of SAHS of patients\nwere compared between the two groups. Compared with group D, mean arterial pressure (MAP) and blood oxygen saturation\n(SPO2) of patients in the P group were lower at the time point of T1 (P < 0.05), the duration of endoscopic examination and wakeup\ntime of patientswere obviously prolonged, the incidence of mask ventilation for patients and false positive cases of SAHS of patients\nwas observably higher, and the satisfaction of endoscopic performerswasmarkedly lower, but the time to fall asleep was significantly\nshortened (P < 0.05). Dexmedetomidine served as a novel sleep induced drug and can provide satisfactory conditions and be safely\nand effectively applied for endoscopy in patients with SAHS, without adverse hemodynamic effects.
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