Theobjective of this study was to determine the point after sugammadex administration atwhich sufficient or insufficient dose could\r\nbe determined, using first twitch height of train-of-four (T1 height) or train-of-four ratio (TOFR) as indicators. Groups A and B\r\nreceived 1mg/kg and 0.5mg/kg of sugammadex, respectively, as a first dose when the second twitch reappeared in train-of-four\r\nstimulation, andGroups C andDreceived 1mg/kg and 0.5mg/kg of sugammadex, respectively, as the first dose at posttetanic counts\r\n1ââ?¬â??3. Five minutes after the first dose, an additional 1mg/kg of sugammadex was administered and changes in T1 height and TOFR\r\nwere observed. Patients were divided into a recovered group and a partly recovered group, based on percentage changes in T1 height\r\nafter additional dosing. T1 height and TOFR during the 5 min after first dose were then compared. In the recovered group, TOFR\r\nexceeded 90% in all patients at 3 min after sugammadex administration. In the partly recovered group, none of the patients had a\r\nTOFR above 90% at 3 min after sugammadex administration. An additional dose of sugammadex can be considered unnecessary\r\nif the train-of-four ratio is =90% at 3 min after sugammadex administration. This trial is registered with UMIN000007245.
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