Although tissue-derived high mobility group box 1 (HMGB1) is involved in many aspects of inflammation and tissue injury after\ntrauma, its role in trauma-induced immune suppression remains elusive. Using an established mouse model of peripheral tissue\ntrauma, which includes soft tissue and fracture components, we report here that treatment with anti-HMGB1 monoclonal antibody\nameliorated the trauma-induced attenuated T-cell responses and accumulation of CD11b+Gr-1+ myeloid-derived suppressor cells in\nthe spleens seen two days after injury. Our data suggest that HMGB1 released after tissue trauma contributes to signaling pathways\nthat lead to attenuation of T-lymphocyte responses and enhancement of myeloid-derived suppressor cell expansion.
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