Surgical brain injury (SBI) is unavoidable during many neurosurgical procedures intrinsically linked to postoperative neurological\ndeficits. We have previously demonstrated that implantation of collagen glycosaminoglycan (CG) following surgical brain injury\ncould significantly promote functional recovery and neurogenesis. In this study we further hypothesized that this scaffold may\nprovide a microenvironment by promoting angiogenesis to favor neurogenesis and subsequent functional recovery. Using the\nrodent model of surgical brain injury as we previously established, we divided Sprague-Dawley male rats (weighting 300ââ?¬â??350 g)\ninto three groups: (1) sham (2) surgical injury with a lesion (L), and (3) L with CG matrix implantation (L + CG). Our results\ndemonstrated that L + CG group showed a statistically significant increase in the density of vascular endothelial cells and blood\nvessels over time. In addition, tissue concentrations of angiogenic growth factors (such as VEGF, FGF2, and PDGF) significantly\nincreased in L + CG group.These results suggest that implantation of a CG scaffold can promote vascularization accompanied by\nneurogenesis. This opens prospects for use of CG scaffolds in conditions such as brain injury including trauma and ischemia
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