Anaphylaxis is a serious life-threatening allergic disease in children. This study is aimed at determining the characteristics of\npediatric patients who experienced anaphylaxis along with treatments administered in order to determine the usefulness of\ntryptase level assessment as a marker of anaphylaxis in Korean children. A total of 107 patients who were diagnosed with\nanaphylaxis in a single pediatric emergency center over a 3-year period were included in the study. Patient clinical\ncharacteristics, symptoms, signs, allergy history, trigger factors, treatments, and laboratory findings, including serum tryptase\nlevels, were included in the analysis. Food allergies (39.3%) were the most commonly reported patient allergic history, and 58\npatients (54.2%) were triggered by food. Among this group, nuts and milk exposure were the most common, affecting 15\npatients (25.9%). History of anaphylaxis and asthma were more common in severe anaphylaxis compared to mild or moderate\nanaphylaxis cases. Epinephrine intramuscular injection was administrated to 76 patients (71.0%), and a self-injectable\nepinephrine was prescribed to 18 patients (16.8%). The median tryptase level was 4.80 ng/mL (range: 2.70â??10.40) which was\nlower than the 11.4 ng/mL value commonly documented for standard evaluation in adults with anaphylaxis. The most common\ncause of pediatric anaphylaxis was food including nuts and milk. The rate of epinephrine injection was relatively high in our\npediatric emergency department. The median tryptase level associated with anaphylaxis reactions in children was lower than\n11.4 ng/mL. Further studies are needed to help improve diagnostic times and treatment accuracy in pediatric patients who\ndevelop anaphylaxis
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