The syndrome of inappropriate antidiuretic hormone (SIADH) is a disease characterized by hyponatremia and hyperosmolarity\nof urine where vasopressin and angiotensin II are implicated in the alteration of salt water balance and cardiovascular and blood\npressure regulation. The aim of this study is to analyse the expression of substances related with cardiovascular and salt water\nregulation in the subfornical organ in a case of SIADH. Two brains, one taken from a 66-year-old man with SIADH and the other\nfrom a 63-year-old man without SIADH, were used. Immunohistochemical study was performed using anti-angiotensin II, antivasopressin,\nand anti-collagen-VI as primary antibodies. Angiotensin and vasopressin immunoreaction were found in neurons, in\nperivascular spaces, and in the ependymal layer in the subfornical organ in both cases.However, in the SIADH case, the angiotensin\nII and collagen-IV expression in the SFO were different suggesting this organ�s possible participation in the physiopathology of\nSIADH.
Loading....