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Inventi Impact: Endocrinology

Articles

  • Inventi:hec/21573/17
    Neonatal and Obstetric Outcomes in Diet- and Insulin-Treated Women with Gestational Diabetes\nMellitus: A Retrospective Study
    01-Jan-1970 Research 2017 : January - March
    Sarah H Koning, Klaas Hoogenberg, Kirsten A Scheuneman, Mick G Baas, Fleurisca J Korteweg, Krystyna M Sollie, Bertine J Schering, Aren J van Loon, Bruce H R Wolffenbuttel, Paul P van den Berg, Helen L Lutgers

    Background: To evaluate the neonatal and obstetric outcomes of pregnancies complicated by gestational diabetes\nmellitus (GDM). Screening and treatment ââ?¬â?? diet-only versus additional insulin therapy ââ?¬â?? were based on the 2010\nnational Dutch guidelines.\nMethods: Retrospective study of the electronic medical files of 820 singleton GDM pregnancies treated between\nJanuary 2011 and September 2014 in a university and non-university hospital. Pregnancy outcomes were compared\nbetween regular care treatment regimens ââ?¬â??diet-only versus additional insulin therapy- and pregnancy outcomes of\nthe Northern region of the Netherlands served as a reference population.\nResults: A total of 460 women (56 %) met glycaemic control on diet-only and 360 women (44 %) required\nadditional insulin therapy. Between the groups, there were no differences in perinatal complications (mortality, birth\ntrauma, hyperbilirubinaemia, hypoglycaemia), small for gestational age, large for gestational age (LGA), neonate\nweighing >4200 g, neonate weighing ââ?°Â¥4500 g, Apgar score <7 at 5 min, respiratory support, preterm delivery, and\nadmission to the neonatology department. Neonates born in the insulin-group had a lower birth weight compared\nwith the diet-group (3364 vs. 3467 g, p = 0.005) and a lower gestational age at birth (p = 0.001). However, birth\nweight was not different between the groups when expressed in percentiles, adjusted for gestational age,\ngender, parity, and ethnicity. The occurrence of preeclampsia and gestational hypertension was comparable\nbetween the groups. In the insulin-group, labour was more often induced and more planned caesarean\nsections were performed (p = 0.001). Compared with the general obstetric population, the percentage of LGA\nneonates was higher in the GDM population (11.0 % vs.19.9 %, p = <0.001).\nConclusions: Neonatal and obstetric outcomes were comparable either with diet-only or additional insulin\ntherapy. However, compared with the general obstetric population, the incidence of LGA neonates was\nsignificantly increased in this GDM coho

    How to Cite this Article
    CC Compliant Citation: Koning, Sarah H., et al. \"Neonatal and\nobstetric outcomes in diet-and insulin-treated women with\ngestational diabetes mellitus: a retrospective study.\" BMC\nEndocrine Disorders 16.1 (2016): 52, DOI 10.1186/\ns12902-016-0136-4, https://creativecommons.org/licenses/\nby/4.0/.
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