Background: Ovarian reserve, vital for reproductive function, can be adversely affected by thyroid diseases. Despite\nalternations of thyroid hormones with ageing, data on interactions between the overtime trend of thyroid functions\nand ovarian reserve status has rarely been reported. We aimed to examine the overtime trend of thyroid hormones,\nthyroid peroxidase antibody (TPO Ab) and their associations with ovarian reserve status, identified by levels of age\nspecific anti-mullerian hormone (AMH) in reproductive aged women, who participated in 12-year cohort of Tehran\nThyroid Study (TTS).\nMethods: Reproductive age women(n = 775) without any thyroid disease or ovarian dysfunction were selected\nfrom the Tehran Thyroid Study cohort. Participants were divided into four age specific AMH quartiles (Q1-Q4), Q1,\nthe lowest and Q4, the highest. AMH was measured at the initiation of study and thyroid stimulating hormone\n(TSH), free T4 (FT4), and TPO Ab were measured at baseline and at three follow up visits.\nResults: At baseline, there was no statistically significant difference in thyroid hormones between women of the\nfour quartiles, although TPO Ab levels were higher in women of Q1. During the follow ups, FT4 was decreased in\nall quartiles (p < 0.05), whereas TPO Ab increased in Q1 (p = 0.02). Odds ratio of overall TPO Ab positivity in women\nof Q1 was 2.08 fold higher than those in Q4. (OR: 2.08, 95%CI: 1.16, 3.72; p = 0.01).\nConclusion: Women with the lowest ovarian reserves had higher levels of TPO Ab, with a positive trend of this\nantibody overtime in comparison to other quartiles, indicating that this group may be at a higher risk of\nhypothyroidism over time.
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