High-fructose diet is known to produce cardiovascular and metabolic pathologies. The objective was to determine whether the\r\ntiming of high fructose (10% liquid solution) intake affect the metabolic and cardiovascular outcomes. Male C57BL mice with\r\nradiotelemetric probes were divided into four groups: (1) 24 h water (control); (2) 24 h fructose (F24); (3) 12 h fructose during\r\nthe light phase (F12L); (4) 12 h fructose during the dark phase (F12D). All fructose groups had higher fluid intake. Body weight\r\nwas increased in mice on restricted access with no difference in total caloric intake. Fasting glycemia was higher in groups with\r\nrestricted access. F24 mice showed a fructose-induced blood pressure increase during the dark period. Blood pressure circadian\r\nrhythms were absent in F12L mice. Results suggest that the timing of fructose intake is an important variable in the etiology of\r\ncardiovascular and metabolic pathologies produced by high fructose consumption.
Loading....