The present study investigates the relationship between diabetes metabolic control represented by levels of HbA1c, early glycation\r\nproducts-(fructosamine (FAM)), serum-advanced glycation end products (s-AGEs), lipoperoxidation products (LPO), advanced\r\noxidation protein products (AOPP) and circulating TGF-Ã?Ÿ in young patients with DM1. The study group consisted of 79 patients\r\nwith DM1 (8ââ?¬â??18 years). 31 healthy children were used as control (1ââ?¬â??16 years). Baseline characteristics of patients were compared\r\nby Studentââ?¬â?¢s t-test and nonparametric Mann-Whitney test (Statdirect), respectively. The correlations between the measured\r\nparameters were examined using Pearson correlation coefficient r and Spearmanââ?¬â?¢s rank test, respectively. A P value < 0.05\r\nwas considered as statistically significant. HbA1c was measured by LPLC, s-AGEs spectrofluorimetrically, LPO and AOPP\r\nspectrophotometrically and TGF-Ã?Ÿ by ELISA. Our results showed that parameters of glycation and oxidation are significantly\r\nhigher in patients with DM1 than in healthy control. The level of serum TGF-Ã?Ÿ was significantly higher in diabetics in comparison\r\nwith control: 7.1(3.6; 12.6) versus 1.6(0.8; 3.9) ng/mL. TGF-Ã?Ÿ significantly correlated with age and duration of DM1. There was\r\nnot found any significant relation between TGF-Ã?Ÿ and parameres of glycation and oxidation. However, these results do not exclude\r\nthe association between TGF-Ã?Ÿ and the onset of diabetic complications.
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