Background: Multidisciplinary intervention is an alternative for the treatment of children and adolescent obese.\r\nHowever, the influence of age and menarcheal status in the pattern of metabolic response of obese girls has not\r\nbeen investigated. The following study examined the effects of a 12-week multidisciplinary intervention on\r\nmetabolic health in overweight girls and the contribution of age and menarcheal status on the resulting changes.\r\nMethods: Eighty-eight overweight girls (10 - 16 years) were considered initially for this study and randomly\r\nassigned (intervention group: n = 58; control group: n = 30). Forty-six girls completed the intervention program and\r\n16 girls completed the follow-up for the control group. The 12-week intervention included aerobic exercises (three\r\ntimes per week) and nutritional intervention. Anthropometrical measures (body mass, body mass index and waist\r\ncircumference), menarcheal status and metabolic profiles including glucose, insulin, triglycerides (TG), total\r\ncholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were\r\nassessed in the beginning and after of intervention. Additionally, were calculated homeostatic model assessmentinsulin\r\nresistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI).\r\nResults: After 12-week, girls decreased significantly the body mass (76.6 �± 14.7 to 75.7 �± 14.6 kg) body mass index\r\n(30.1 �± 4.0 to 29.4 �± 4.0 kg/m2) and waist circumference (98.9 �± 10.9 to 96.5 �± 11.4 cm). There were differences in\r\nHDL-C (43.1 �± 8.2 to 50.3 �± 9.4 mg/dl), TG (120.9 �± 64.3 to 93.3 �± 47.9 mg/dl) and insulin (16.9 �± 7.6 to 15.6 �± 9.8 mg/\r\ndl). Relative contribution of age was significant only for within-subject variability in waist circumference.\r\nConclusions: The multidisciplinary based on aerobic training intervention used in this study produced substantial\r\nbenefits on metabolic health indicators in overweight girls. The changes observed were not related to interindividual\r\nvariability in age and maturity status.
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