PC (pancreatic cancer) is the fourth most common cause of death due to cancer worldwide. The incidence and mortality rates\nhave been increasing year by year worldwide, and this review has analyzed the most recent incidence and mortality data for\npancreatic cancer occurrence in China. Several possible risk factors have been discussed here, involving known established risk\nfactors and novel possible risk factors. The development of this cancer is a stepwise progression through intraepithelial neoplasia to\ncarcinoma.Though early and accurate diagnosis is promising based on a combination of recent techniques including tumor markers\nand imaging modalities, lacking early clinical symptoms makes the diagnosis late. Correct staging is critical because treatment\nis generally based on this parameter. Treatment options have improved throughout the last decades. However, surgical excision\nremains the primary therapy and efficacy of conventional chemoradiotherapy for PC is limited. Recently, some novel new therapies\nhave been developed and will be applied in clinics soon. This review will provide an overview of pancreatic cancer, including an\nunderstanding of the developments and controversies.
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