Researchers have made considerable progress in last few decades in understanding mechanisms underlying pathogenesis of\nbreast cancer, its phenotypes, its molecular and genetic changes, its physiology, and its prognosis. This has allowed us to identify\nspecific targets and design appropriate chemical entities for effective treatment of most breast cancer phenotypes, resulting in\nincreased patient survivability. Unfortunately, these strategies have been largely ineffective in the treatment of triple negative\nbreast cancer (TNBC). Hormonal receptors lacking render the conventional breast cancer drugs redundant, forcing scientists\nto identify novel targets for treatment of TNBC. Two natural compounds, curcumin and resveratrol, have been widely reported\nto have anticancer properties. In vitro and in vivo studies show promising results, though their effectiveness in clinical settings\nhas been less than satisfactory, owing to their feeble pharmacokinetics. Here we discuss these naturally occurring compounds,\ntheir mechanism as anticancer agents, their shortcomings in translational research, and possible methodology to improve their\npharmacokinetics/pharmacodynamics with advanced drug delivery systems.
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