Objective: To detect the expression and pathological significances of Interleukin-\n6 (IL-6) and basic fibroblast growth factor (bFGF) in tongue squamous\ncell carcinoma (TSCC). Methods: A tissue array was analyzed immunohistochemically.\nThe expression levels of IL-6 and bFGF in tissues were recorded\nsemi-quantitatively. Results: The positive expression of IL-6 in normal, benign\ntumor, and carcinoma groups was 12.50% �± 5.575%, 39.00% �± 1.41%,\n77.26% �± 17.07% respectively, and the expression among the three groups\nshowed significant differences (P < 0.05). The expression of bFGF in benign\ntumor was lower than that in normal groups and squamous cell carcinoma.\nThe positive expression was 6.50% �± 2.12%, 23.75% �± 4.79%, 42.33% �±\n29.89% respectively, and the expression among the three groups showed significant\ndifferences (P < 0.05). Furthermore, there were positive correlations\nbetween IL-6 and bFGF (P < 0.05). Conclusion: It indicates that combining\nimmunohistochemical examination of IL-6 and bFGF has an important reference\nvalue on the pathological diagnosis of tongue squamous cell carcinoma.
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