The protein tyrosine phosphatase (PTP) family is involved in multiple cellular functions\nand plays an important role in various pathological and physiological processes. In many chronic\ndiseases, for example cancer, PTP is a potential therapeutic target for cancer treatment. In the last two\ndecades, dozens of PTP inhibitors which specifically target individual PTP molecules were developed\nas therapeutic agents. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors\nand is the second most lethal cancer worldwide due to a lack of effective therapies. Recent studies\nhave unveiled both oncogenic and tumor suppressive functions of PTP in HCC. Here, we review the\ncurrent knowledge on the involvement of PTP in HCC and further discuss the possibility of targeting\nPTP in HCC.
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