Germ-cell tumors (GCTs) are highly curable with chemotherapy. Salvage chemotherapy or surgery can cure a proportion of\npatients, but the ones failing these treatments will die of their disease in the young age. Immune checkpoint pathways are emerging\nas powerful targetable biomarkers, and a significant preclinical and clinical research is underway to widen our knowledge and\nexpand the treatment possibilities with immune therapy. The concept of immune modulation that was currently adopted in many\nsolid tumors is understudied in GCTs. Herein, we summarize the current knowledge of published literature discussing the\nimmune mechanisms and immune therapy in GCTs.
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