Metastasis is the most deadly aspect of cancer and results from acquired gene regulation abnormalities in tumor cells.\nTranscriptional regulation is an essential component of controlling of gene function and its failure could contribute to tumor\nprogression and metastasis. During cancer progression, deregulation of oncogenic or tumor suppressive transcription factors, as\nwell as master cell fate regulators, collectively influences multiple steps of the metastasis cascade, including local invasion and\ndissemination of the tumor to distant organs. Transcription factor PAX3/Pax3, which contributes to diverse cell lineages during\nembryonic development, plays a major role in tumorigenesis. Mutations in this gene can cause neurodevelopmental disease and\nthe existing literature supports that there is a potential link between aberrant expression of PAX3 genes in adult tissues and a wide\nvariety of cancers. PAX3 function is tissue-specific and could contribute to tumorigenesis either directly as oncogene or as a tumor\nsuppressor by losing its function. In this review, we discuss comprehensively the differential role played by PAX3 in various tissues\nand how its aberrant expression is implicated in disease development. This review particularly highlights the oncogenic and tumor\nsuppressor role played by PAX3 in different cancers and underlines the importance of precisely identifying tissue-specific role of\nPAX3 in order to determine its exact role in development of cancer.
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