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Inventi Impact: Oncology

Articles

  • Inventi:hoc/27700/18
    Rectal Cancer: Redox State of Venous Blood and Tissues of Blood Vessels from Electron\nParamagnetic Resonance and Its Correlation with the Five-Year Survival
    Research 2019 : January - March
    A P Burlaka, A V Vovk, A A Burlaka, M R Gafurov, K B Iskhakova, S N Lukin

    A role of pro- and antioxidants for reducing rectal cancer (RC) incidence in operative, preoperative, and postoperative treatments is\nstill disputable and controversial.Theredox state of venous blood and tissues of blood vessels of 60 patientswith RC (T2-4N0-2M0G2)\nand 20 donors is studied by means of the conventional and spin-trapping electron paramagnetic resonance (EPR). The intensity\nof the signals from ceruloplasmin (CP), transferrin (TF), and labile iron pool (LIP) at temperature T = 77 K as well as superoxide\ngeneration rate and nitric oxide (NO) levels at T = 300 K is measured.The reduced CP and TF activity and decreased NO levels\nincreased LIP levels and superoxide-generating rates are detected in blood species.Correlation analysis for the five-year survival rate\nas a function of the extracted values is done.Theresults show that the intensities of the corresponding EPR signals fromthe â??nativeâ?\nand â??trappedâ? paramagnetic centers can be potentially used for the understanding of the molecular mechanisms underlying the\nRC progression and treatment.

    How to Cite this Article
    A. P. Burlaka, A. V. Vovk, A. A. Burlaka, M. R.\nGafurov, K. B. Iskhakova, and S. N. Lukin, â??Rectal Cancer: Redox\nState of Venous Blood and Tissues of Blood Vessels from Electron\nParamagnetic Resonance and Its Correlation with the Five-Year\nSurvival,â? BioMed Research International, vol. 2018, Article ID\n4848652, 7 pages, 2018. https://doi.org/10.1155/2018/4848652,\nhttp://creativecommons.org/licenses/by/4.0/.
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