Objectives. Cancer is a very widespread disorder known in world wide since\nlong, but its biochemical features remain unclear. Thyroid carcinomas are the\nmost common endocrine cancer and its frequency continues to escalate.\nThere is evidence that the serum concentration of TSH is an unreliant predictor\nfor the diagnosis of thyroid cancer. The formation of the plasma thiol\npool from low and large molecular weight proteins suggests that thiol/disulfide\nbalance is important in cancerous cases. The aim of this study was to investigate\nan oxidative stress marker (thiol/disulphide homeostasis) and IMA\n(Ischemia modified albumin), Albumin, CEA (Carcinoembryonic antigen),\nTSH (Thyroid stimulate hormone), thyroxine (T4), free thyroxine (FT4), triiodothyronine\n(T3) and free triiodothyronine (FT3) in patients with thyroid\ncancer and compare the results with healthy controls for the first time in literature.\nMaterials-Methods: A total of 43 participants including 23 patients\nwith thyroid cancer and 20 healthy individuals were included in the study.\nSerum levels of TSH, T4, FT4, T3 and FT3 have been measured during treatment\nand follow-up of patients with thyroid carcinoma. Serum levels of TSH,\nT4, FT4, T3 and FT3, IMA, Albumin, CEA, Native thiol (-SH), disulfide (-S-S)\nand total thiol (TT) as well as disulphide/native thiol and disulphide/total\nthiol ratios were compared between the groups. Native thiol, disulfide and\ntotal thiol concentrations were measured with a novel automated method\n(Roche, cobas 501, Mannheim, Germany). Results and conclusion: This paper\ndiscusses a oxidative stress marker (thiol/disulphide homeostasis) and\ntumor markers IMA, Albumin, CEA, TSH, T4, FT4, T3 and FT3 in patients\nwith thyroid cancer and compare the results with healthy controls. Mean age\nat participant was 41.73 years for thyroid cancer patients (21 females/2\nmales). A control group of 20 participants was included the study (19 females/\n1 male, mean age 51.75).
Loading....