The aim of the research is to investigate the expression of the cell cycle relative\nproteins (P53, P16, Cyclin D1, and Ki67) in Esophageal Cancer (EC) patients\nof the Chaoshan area, China. In China, Chaoshan has the high incidence\nof EC. Different areas have shown different rate for expression of these\nproteins in EC. We investigated the expression of p53, p16, cyclinD1, and\nki67 for the first time in Chaoshan. In this research, DNA was extracted from\nformalin fixed and paraffin embedded tissues of esophageal cancer (EC) patients.\nThe expression level of proteins cycle was detected by using immunohistochemistry\n(IHC). And the data was checked byâ?¦â?¦ test or Fisherâ??s exact\ntest of SPSS17.0. The positive immunohistochemical staining of p53, p16,\ncyclinD1, and ki67 were observed in 65.7% 39.2%, 69.1%, and 83.5% specimens\nrespectively. There was a positive correlation between p53 positive\nstaining and p16, cyclinD1, ki67 staining at p < 0.05. CyclinD1 has the high\ncorrelation with ki67 at p < 0.05. A significant inverse correlation was considered\nbetween the expression of p16 and cyclinD1 and there was no correlation\nobserved between p16 and ki67. In Conclusion, this study demonstrated\nthe high expression of p53, Cyclin D1 and Ki67 and low expression of P16\nand the association of these cell cycle relative proteins in esophageal cancer\nare new data in Chaoshan area of China. Geographical distribution of EC on\nthe molecular basis is revealed in this research.
Loading....