Background: Hypoxic preconditioning (HPC) may protect multiple organs from various injuries. We hypothesized\nthat HPC would reduce lung injury in patients undergoing thoracoscopic lobectomy.\nMethods: In a prospective randomized controlled trial, 70 patients undergoing elective thoracoscopic lobectomy\nwere randomly allocated to the HPC group or the control group. Three cycles of 5-min hypoxia and 3-min\nventilation applied to the nondependent lung served as the HPC intervention. The primary outcome was the PaO2/\nFiO2 ratio. Secondary outcomes included postoperative pulmonary complications, pulmonary function, and duration\nof hospital stay.\nResults: HPC significantly increased the PaO2/FiO2 ratio compared with the control at 30 min after one-lung\nventilation and 7 days after operation. Compared with the control, it also significantly improved postoperative\npulmonary function and markedly reduced the postoperative hospital stay duration. No significant differences\nbetween groups were observed in the incidence of pulmonary complications or overall postoperative morbidity.\nConclusions: HPC improves postoperative oxygenation, enhances the recovery of pulmonary function, and reduces\nthe duration of hospital stay in patients undergoing thoracoscopic lobectomy.
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