Background: Some prospective studies have observed associations between periodontal disease and breast cancer.\nTherefore, the aim of the present study was to investigate the composition of the subgingival biofilm of women\ndiagnosed with breast cancer, who also presented with chronic periodontitis.\nMethods: All subjects underwent clinical and microbiological assessment. Subgingival biofilm samples were taken\nfrom at least three sites of 44 women who had breast cancer. The mean levels and proportions of 40 bacterial\nspecies were determined by checkerboard DNA-DNA hybridization. Spearman correlation was used to assess\npossible associations between the mean levels of bacterial species and clinical conditions.\nResults: The five species found at the highest levels were Prevotella nigrescens, Actinomyces gerencseriae, Neisseria\nmucosa, Porphyromonas gingivalis and Tannerella forsythia. The species detected in the lowest counts were\nPropionibacterium acnes, Streptococcus constellatus, Streptococcus intermedius, Eubacterium saburreum and\nStreptococcus anginosus. No significant association between levels and proportion of bacterial species and clinical\nparameters were found.\nConclusion: In conclusion, the results of the present study found no direct association between the subgingival\nmicrobiota and breast cancer and an indirect pathway should be addressed in further studies.
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