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Inventi Impact: Oncology

Articles

  • Inventi:hoc/32449/20
    R269C Variant of ESR1: High Prevalence and Differential Function in a Subset of Pancreatic Cancers
    Research 2020 : October - December
    Tomer Boldes, Keren Merenbakh-Lamin, Shani Journo, Eliya Shachar, Doron Lipson, Adva Yeheskel, Metsada Pasmanik-Chor, Tami Rubinek, Ido Wolf

    Estrogen receptor Alpha (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in\nthe development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge region,\nconnecting the ligand binding and DNA domains. rs142712646 is a rare SNP in ESR1, which leads to a substitution\nof arginine to cysteine at amino acid 269 (R269C). The mutation is positioned in the hinge region of ESR1, hence\nmay affect the receptor structure and function. We aimed to characterize the activity of R269C-ESR1 and study its\nrole in the development of pancreatic cancer.................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Boldes, Tomer, et al. \"R269C variant of ESR1: high prevalence and differential function in a\nsubset of pancreatic cancers.\" BMC Cancer 20.1 (2020): 1-15.\nhttps://doi.org/10.1186/s12885-020-07005-x\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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