Prognosis prediction of squamous cell carcinoma (SCC) with mandibular invasion is\ncontroversial, and a more sophisticated staging system to aid prognosis could be developed with\nimaging characteristics of bone invasion. Imaging-feature analysis provides practical, stratified\nresults for survival prognosis in oral SCC (OSCC) of the mandible, and imaging advances enable\nmore detailed tumor visualization. We retrospectively evaluated significant bone-invasion features\nassociated with poor outcomes in mandibular OSCC to assess the predictive value of staging criteria\nthat combined imaging features and histologic grade (combined imagingâ??histology (IH) grade) in\n65 patients (39 men, 26 women) with mandibular SCC diagnosed from 2006 to 2016.\nClinicopathologic features, including T-stage and histologic grade, and prognosis were retrieved.\nTumors were classified into three types by extent of mandibular invasion on pretreatment imaging\nstudies. Moreover, we assessed the involvement of the mandibular canal. We examined the\ncorrelation of factors associated with locoregional recurrence and overall mortality. The Harrell\nConcordance Index (C-index) determined prognostic performance of predictors. Nineteen (29%)\npatients showed locoregional recurrence and 13 (20%) died. For locoregional recurrence and\nmortality rates, imaging-detected mandibular canal (MC) involvement is a stronger prognostic\nfactor for recurrence.........................
Loading....