Background: Human papillomavirus (HPV) is the necessary cause of cervical cancer. Published data on the\nepidemiology of HPV in women with invasive cervical cancer (ICC) in New Zealand (NZ) are limited. This\ncross-sectional study investigated the distribution of high-risk and low-risk HPV types in cervical specimens collected\nfrom women throughout NZ who had been diagnosed with ICC between 2004 and 2010.\nMethods: Women aged ?18 years, with ICC International Federation of Gynecology and Obstetrics stage Ib or\ngreater were identified from the five tertiary public hospitals in NZ regularly treating women with ICC. Women\nwere enrolled in the study only after obtaining informed consent. Stored, formalin fixed, paraffin-embedded cervical\nspecimens were retrieved and histopathologically reviewed to confirm the diagnosis of ICC. Cervical specimens\nwere tested for HPV using polymerase chain reaction-short fragment10; HPV DNA was detected using DNA enzyme\nimmunoassay and typed by reverse hybridization line probe assay.\nResults: 242 women were enrolled and ICC was histologically confirmed in 227 samples. HPV infection was\ndetected in 88.5% (n = 201; 95% CI: 83.7ââ?¬â??92.4) of women with ICC; high-risk HPV types were detected in 87.2% of\nwomen. The most commonly detected HPV types were HPV-16 (51.1%) and HPV-18 (20.7%), followed by HPV-31\n(4.0%), HPV-45 and HPV-52 (3.1% each). Overall, HPV distribution was highest (94.3%) in women aged 30ââ?¬â??39 years at\ndiagnosis and a higher distribution of HPV-16 (68.8%) was observed in women younger than 30 years. The overall\ndistribution of HPV types between Maori and non-Maori women were similar. HPV-positive women with ICC stage II\nor greater were less likely to be infected with HPV-16/18 (P = 0.002) or HPV-18 (P = 0.029) compared with the other\nhigh-risk types. Single type infection and multiple infections were detected in 93.5% and 5.5% of women, respectively.\nConclusions: HPV-16, HPV-18, HPV-31, HPV-45 and HPV-52 were the most commonly detected high-risk HPV types.\nFindings from the study fill an important data gap on HPV type distribution from NZ which will help facilitate better\nunderstanding of the epidemiology of HPV in NZ women.
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