Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder caused by a defect\nin the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. The disease primarily presents with\nrecurrent infections, and patients may also present with inflammatory conditions, including noninfectious colitis, and\nan increased frequency of autoimmunity. We report here a patient with CGD in whom the presentation, unlike the\nclassical presentation of CGD, was predominantly of an inflammatory and autoimmune phenotype.\nCase presentation: A 3-year-old Pakistani female presented with bloody diarrhea since the age of 7 days, followed\nby the development of perianal abscesses and fistula. There was no other history of recurrent infections. The patient\nsubsequently developed joint pain and stiffness with persistently elevated inflammatory markers and elevated anticyclic\ncitrullinate peptide (anti-CCP) antibody titer. She was diagnosed with oligoarticular juvenile idiopathic arthritis\nand colitis. ......................................
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