Tumor acidosis is a consequence of altered metabolism, which can lead to chemoresistance and can be a target of alkalinizing\ntherapies. Noninvasive measurements of the extracellular pH (pHe) of the tumor microenvironment can improve diagnoses and\ntreatment decisions.A variety of noninvasive imaging methods have been developed for measuring tumor pHe. This review provides\na detailed description of the advantages and limitations of each method, providing many examples from previous research reports.\nA substantial emphasis is placed on methods that use MR spectroscopy and MR imaging, including recently developed methods\nthat use chemical exchange saturation transfer MRI that combines some advantages of MR spectroscopy and imaging. Together,\nthis review provides a comprehensive overview of methods for measuring tumor pHe, which may facilitate additional creative\napproaches in this research field.
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