Technological advances in magnetic resonance imaging (MRI) and computed tomography (CT), including higher spatial and\ntemporal resolution, have made the prospect of performing absolute myocardial perfusion quantification possible, previously\nonly achievable with positron emission tomography (PET). This could facilitate integration of myocardial perfusion biomarkers\ninto the current workup for coronary artery disease (CAD), as MRI and CT systems are more widely available than PET\nscanners. Cardiac PET scanning remains expensive and is restricted by the requirement of a nearby cyclotron. Clinical evidence\nis needed to demonstrate that MRI and CT have similar accuracy for myocardial perfusion quantification as PET. However, lack\nof standardization of acquisition protocols and tracer kinetic model selection complicates comparison between different studies\nand modalities. The aim of this overview is to provide insight into the different tracer kinetic models for quantitative myocardial\nperfusion analysis and to address typical implementation issues in MRI and CT. We compare different models based on their\ntheoretical derivations and present the respective consequences for MRI and CT acquisition parameters, highlighting the interplay\nbetween tracer kinetic modeling and acquisition settings.
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