The aim of this study was to assess with MRI morphometric ultrastructural changes in nerves affected by diabetic peripheral\nneuropathy (DPN).We used an MR micro-neurography imaging protocol and a semiautomated technique of tissue segmentation\nto visualize and measure the volume of internal nerve components, such as the epineurium and nerve fascicles. The tibial nerves\nof 16 patients affected by DPN and of 15 healthy volunteers were imaged. Nerves volume (NV), fascicles volume (FV), fascicles to\nnerve ratio (FNR), and nerves cross-sectional areas (CSA) were obtained. In patients with DPN the NV was increased and the FNR\nwas decreased, as a result of an increase of the epineurium (FNR in diabetic neuropathy 0,665; in controls 0,699,
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