Background: The American Society of Nuclear Cardiology and the Society of Nuclear Medicine state that\r\nincorporation of attenuation-corrected (AC) images in myocardial perfusion scintigraphy (MPS) will improve image\r\nquality, interpretive certainty, and diagnostic accuracy. However, commonly used software packages for MPS\r\nusually include normal stress databases for non-attenuation corrected (NC) images but not for attenuationcorrected\r\n(AC) images. The aim of the study was to develop and compare different normal stress databases for\r\nMPS in relation to NC vs. AC images, male vs. female gender, and presence vs. absence of obesity. The principal\r\nhypothesis was that differences in mean count values between men and women would be smaller with AC than\r\nNC images, thereby allowing for construction and use of gender-independent AC stress database.\r\nMethods: Normal stress perfusion databases were developed with data from 126 male and 205 female patients\r\nwith normal MPS. The following comparisons were performed for all patients and separately for normal weight vs.\r\nobese patients: men vs. women for AC; men vs. women for NC; AC vs. NC for men; and AC vs. NC for women.\r\nResults: When comparing AC for men vs. women, only minor differences in mean count values were observed,\r\nand there were no differences for normal weight vs. obese patients. For all other analyses major differences were\r\nfound, particularly for the inferior wall.\r\nConclusions: The results support the hypothesis that it is possible to use not only gender independent but also\r\nweight independent AC stress databases.
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