Background: Recent studies have highlighted the correlation between diabetes and pancreatic fat infiltration.\nNotably, pancreatic fat content (PFC) is a potential biomarker in diabetic patients, and magnetic resonance imaging\n(MRI) provides an effective method for noninvasive assessment of pancreatic fat infiltration. However, most reports\nof quantitative measurement of pancreatic fat have lacked comparisons of pathology results. The primary objective\nof this study was to determine the feasibility and accuracy of pancreatic MRI by using pancreatic fat fraction (PFF)\nmeasurements with the IDEAL-IQ sequence; the secondary objective was to explore changes in PFC between pigs\nwith and without diabetes.\nMethods: In this prospective study, 13 Bama Mini-pigs (7 females, 6 males; median age, 2 weeks) were randomly\nassigned to diabetes (n = 7) or control (n = 6) groups. Pigs in the diabetes group received high fat/high sugar feed,\ncombined with streptozotocin injections. At the end of 15 months, biochemical changes were evaluated. All pigs\nunderwent axial MRI with the IDEAL-IQ sequence to measure PFF; PFC of fresh pancreatic parenchyma was\nmeasured by the Soxhlet extraction method; and pancreatic fat distribution was observed by histopathology.\nResults of all analyses were compared between the diabetes and control groups by using the Mann-Whitney U-test.\nCorrelations of PFF and PFC, fasting blood glucose (GLU), and serum insulin (INS) were calculated by using the\nSpearman correlation coefficient. Single-measure intraclass correlation coefficient (ICC) was used to assess\ninterreader agreement.......................
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