Background: The associations between the severity of interstitial lung disease\nand the stage and histologic type of concurrent lung cancer remain unknown.\nPurpose: To evaluate whether the severity of interstitial lung abnormality\n(ILA), as indicated by quantitative computed tomographic (CT) indexes and\nCT visual score, was correlated with the stage and histological type of concurrent\nlung cancer. Materials and Methods: Twenty-eight patients with\nsurgically diagnosed lung cancer and ILA on CT were enrolled in this retrospective\nstudy. The subjects were allocated to one of three groups by histological\ntype: adenocarcinoma group (13 subjects); squamous cell carcinoma\ngroup (10 subjects); and the other histological diagnosis group (5 subjects).\nTwo independent observers evaluated the CT findings to determine the CT\nvisual score, and the kurtosis and skewness of CT-based density histograms\nwere determined. The relationships between severity of ILA and the pathological\nstage and histological type of concurrent lung cancer were evaluated.\nResults: There were no significant differences in the CT visual scores and\nquantitative indexes among the three groups. CT visual score was significantly\nnegatively correlated with pathological stage (r =-0.43, P = 0.025). Conclusion:\nPatients can have only mild ILA on visual scoring but advanced lung\ncancer. Therefore, the frequency of follow-up examination should not be\nbased on the severity of ILA on CT.
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