A novel quantitative fluorescence molecular tomography (FMT) imager for both macro and meso-scale animal\r\nexperiments is developed. The image reconstruction algorithms are implemented in the framework of finite element\r\nmethod, while the experimental system is constructed using a non-contact, multi-angle full 360 degree transmission\r\nscheme. Shape-from-silhouette based volume carving approach is used to render the 3D models of the actual\r\nsamples. With a free-space light propagation model, the readout from the CCD is converted into the photon density\r\nnormal to sample surface in order to match the model-based tomographic reconstruction. For meso-scale subjects, a\r\nradiative transfer equation (RTE) based FMT reconstruction algorithm is adopted. For macro-scale subjects, a diffusion\r\napproximation (DA) based FMT reconstruction algorithm is adopted. Imaging results for both macro-scale and mesoscale\r\nsubjects are presented to valid system performance.
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