Background: To evaluate the contrast agent performance of Gd-EOB-DTPA and Gd-BOPTA for detection and\r\nassessment of extrahepatic findings, semi-quantitatively and qualitatively.\r\nMethods: 13 patients with 19 extrahepatic lesions underwent liver MRI with Gd-EOB-DTPA and Gd-BOPTA.\r\nQuantitative and relative SNR measurements were performed in each dataset in the arterial and portalvenous phase\r\nwithin the extrahepatic lesion, aorta, inferior vena cava, portal vein, spleen, pancreas and renal cortex. Further,\r\nrelative CNR measurements were performed. Three readers assessed contrast quality using a five-point scale and\r\nchoosing the preferred image dataset. Statistical analysis consisted of a Student�s t-test with p < 0.05 deemed\r\nsignificant, a weighted kappa statistic for assessment of interobserver variability and an ROC analysis.\r\nResults: Mean SNR after injection of Gd-BOPTA was significantly higher compared with Gd-EOB-DTPA for all\r\nmeasurements (p < 0.05). Mean relative SNR was also higher for Gd-BOPTA, but without being statistically\r\nsignificant. There was no significant difference in relative CNR. Interobserver agreement for selection of image\r\npreference was moderate (mean weighted kappa 0.485). The area under the curve for the ROC-analysis regarding\r\ncontrast agent performance was 0.464.\r\nConclusion: Even though mean SNR is significantly higher after injection of Gd-BOPTA compared with Gd-EOB\r\n-DTPA, there is no significant difference in relative CNR with extrahepatic lesions being assessed equally well. Visual\r\nimpression may differ after injection of Gd-EOB-DTPA, but does not influence image interpretation. Extrahepatic\r\nfindings can be assessed similarly to MRI after injection of Gd-BOPTA.
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