Background. The pro- and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection.\nThe proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric\ninflammation. Objective. The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10,\nIL-17, IL-21, IL-23, and TNF-�±) in H. pylori-infected patients and healthy controls and to understand their association with\nH. pylori infection and disease severity. Results. The expression levels of IL-17 and IL-23 were significantly higher in H. pyloriinfected\npatients. The expression of IL-21 was also higher in H. pylori-positive patients but there was no significant\nassociation with infection. IL-17 expression showed a significant increase with the severity of chronic gastritis. Conclusion.\nThe proinflammatory cytokine, IL-17, shows a significant association with H. pylori infection and disease severity in a Sri\nLankan dyspeptic patient population.
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