Spirocyclic compounds are experiencing a research surge due to their unique 3D structure, offering enhanced pharmacological, industrial, and material applications. They are increasingly used in medicinal chemistry to improve drug-like properties, such as solubility and target binding, and are also being utilized for advanced material applications, including electronics and photonics. In this communication, 3-(4-hydroxyphenyl)-1,3,6-trimethyl- 2H,3H,4H-spiro[furo[3,2-c]pyran-2,5-pyrimidine]-2,4,4,6(1H,3H)-tetraone was prepared via a two-stage transformation including a tandem Knoevenagel–Michael reaction and NBSinduced cyclization. At the first stage, a previously unknown ionic scaffold, morpholin-4- ium 5-((4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)(4-hydroxyphenyl)methyl)-1,3-dimethyl- 2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate was also isolated. Structures of the newly synthesized compounds were established by 1H and 13C NMR, IR spectroscopy, highresolution mass spectrometry, and elemental analysis.
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