We synthesized some novel flavanones incorporated semicarbazide derivatives (Y2e–Y2j). The derivatives were characterized by physico-chemical (TLC and melting point) and spectral analysis (I.R., N.M.R and mass spectroscopy) and finally the biological activities were performed by using different animal models like pentylenetetrazole-induced convulsions in rats for anti-convulsant activity and tail immersion method for analgesic activity respectively and compared with the standard drugs diazepam and diclofenac sodium. Compound Y2g, Y2h, Y2j i.e., ({4-(dimethylamino)phenyl}, {2-phenyl-2,3-dihydro} and 4-hydroxy-3-methoxyphenyl) and Compound Y2e, Y2f, Y2g i.e., (4-nitrophenyl, 4-hydroxyphenyl, [4-(dimethylamino)phenyl] ) substitution was found to have more significant results as comparable to standard drug diazepam and diclofenac sodium respectively. A flavanone found in orange juice, may significantly reduce blood pressure and other cardiovascular disease risk factors. Moreover number of studies has shown a protective effect of polyphenol-rich foods, including tea, wine and chocolate against cardiovascular diseases (CVDs).
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