1, 3, 4 – Oxadiazole mainly based on a Heterocyclic ring system. In the structure of oxadiazole there are two nitrogen fused with oxygen. Oxadiazole have accelerated interest in various field like medicinal chemistry, polymer industry etc. Heterocyclic compounds have been an interesting area for the study of synthesis and biological activity of novel oxadiazole derivatives for a long time. Oxadiazole are the major compound of heterocyclic nucleus for the development of new drugs and the drugs of oxadiazole were the first effective chemotherapeutic agent to be employed systemically for the prevention & cure of bacterial infection. The heterocyclic compound has been known for several years and investigations in field have been identified due to the large no. of uses & application in most diverse area. Literature survey reveals that the compound are well known to have a no. of broad spectrum biological activities like as antibacterial, anti-inflammatory, anticonvulsant, anticancer, ant tubercular, anti-diabetic, anthelmintic, analgesic etc. Therefore, the synthesis of new 2, 5-di-substituted 1, 3,4oxadiazole derivatives that possess a promising biological activity for the future development to get safer & effective compounds.
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