In the present investigation, A series Novel Schiff’s bases 3-[substituted (phenyl methylidene] amino} ethyl) amino] quinoxalin-2(1H)-one have been synthesized by Phillips condensation mechanism. And in further step of synthesis Schiff’s bases were synthesized by reacting with series aromatic aldehydes. Final derivatives were screened for their in- vitro anti bacterial activity against range of Gram positive and Gram negative as well as for their anti fungal activity against a clinical isolate of Candida albicans species. All the compounds were characterized by IR and 1H NMR spectroscopic data. The compound IIIe is highly active against E. coli. The compound IIIe and IIIf highly active against B.amylase .compounds IIIa, IIIf are highly active against P. aerogenosa. The compound IIIb and IIIf highly active against fungal stain C.albicans.
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