It was aimed to comparatively evaluate the effects of dressing methods with silver sulfadiazine, povidone-iodine, and saline which\nhave a common use in routine practices for burn injuries. Twenty-eight Sprague Dawley adult female rats were used in this study.\nAll the rats were divided into 4 groups: the control group, the povidone-iodine group, the saline group, and the silver sulfadiazine\ngroup. On each rat, a second degree burn which covered less than 10% of the body surface area was created under general anesthesia\nby a metal comb including four probes with 2 Ã?â?? 1 cm area. The control group did not have any treatment during the experiment.\nPovidone-iodine, saline, and silver sulfadiazine administrations were performed under ether anesthesia every day. On 0, 7th, 14th,\nand 21st days of the study, tissue samples were taken for histological analyses. The sections taken from the paraffin blocks were\nstained and avidin-biotin-peroxidase method was used for collagen immune-reactivity. In the light microscope analyses, number\nof inflammatory cells, vascularization, fibroblast proliferation, collagen formation and epithelializationwere evaluated histologically\nin all groups and analysed statistically. The agents that we used for injury healing in the treatment groups did not show any\nsignificant better results in comparison with the control group. In conclusion, further studies with the use of sodium chloride,\nsilver sulfadiazine, and povidone-iodine by creating deeper and/or larger burn injury models are needed in order to accept these\nagents in routine treatment.
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