Intense pulsed light (IPL) has been used extensively in aesthetic and cosmetic dermatology. To test whether IPL could change the\ntissue vascularity and improve wound healing, mice were separated into 4 groups. Mice in Group I were not treated with IPL,\nwhereas, dorsal skins of mice in Groups II, III, and IV were treated with 35 J/cm2, 25 J/cm2, and 15 J/cm2 IPL, respectively. After 2\nweeks, dorsal island skin flaps were raised, based on the left deep circumflex iliac vessels as pedicles; then, survival rate was assessed.\nFlaps in Group IV (treated with lowest dose of IPL) have a survival rate significantly higher than other groups. Counting blood\nvessels did not demonstrate any significant differences; however, vessel dilation was found in this group. The results show that IPL\nat the therapeutic doses which are usually applied to humans is harmful to mouse dorsal skin and did not enhance wound healing,\nwhereas, IPL atmuch lower dose could improve wound healing.Thepossible mechanism is the dilation of tissue vasculature thanks\nto the electromagnetic character of IPL. Another mechanism could be the heat-shock protein production.
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