Background: Pancreatic ductal adenocarcinoma (PDAC) patients frequently present with borderline resectable\ndisease, which can be due to invasion of the portal/superior mesenteric vein (PV/SMV). Here, we analyzed this\ngroup of patients, with emphasis on short and long-term outcomes.\nMethods: 156 patients who underwent a resection for PDAC were included in the analysis and sub-stratified into a\ncohort of patients with PV/SMV resection (n = 54) versus those with standard surgeries (n = 102).\nResults: While venous resections could be performed safely, there was a trend towards shorter median survival in the\nPV/SMV resection group (22.7 vs. 15.8 months, p = 0.157). These tumors were significantly larger (3.5 vs 4.3 cm; p = 0.026)\nand margin-positivity was more frequent (30.4 % vs 44.4 %, p = 0.046).\nConclusion: Venous resection was associated with a higher rate of margin positivity and a trend towards shorter survival.\nHowever, compared to non-surgical treatment, resection offers the best chance for long term survival.
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