Background: Metastases to the pancreas are rare, accounting for less then 2 % of all pancreatic malignancies.\nHowever, both the benefit of extended tumor resection and the ideal oncological approach have not been\nestablished for such cases; therefore, we evaluated patients with metastasis to the pancreas who underwent\npancreatic resection.\nMethods: Between 1994 and 2012, 676 patients underwent pancreatic surgery in our institution. We retrospectively\nreviewed patientsââ?¬â?¢ medical records according to survival, and surgical and non-surgical complications. Studentââ?¬â?¢s t-test\nand the log-rank test were used for statistical analysis.\nResults: Eighteen patients (2.7 %) received resection for pancreatic metastases (12 multivisceral resections and\n6 standard resections). The pancreatic metastases originated from renal cell carcinoma (n = 10), malignant melanoma\n(n = 2), neuroendocrine tumor of the ileum (n = 1), sarcoma (n = 1), colon cancer (n = 1), gallbladder cancer (n = 1),\ngastrointestinal stromal tumor (n = 1), and non-small cell lung cancer (n = 1). The median time between primary\nmalignancy resection to metastasectomy was 83 months (range, 0ââ?¬â??228 months). Minor surgical complications\n(Grade I-IIIa) occurred in six patients (33.3 %) whereas major surgical complications (Grade IIIb-V) occurred in three\npatients (16.6 %). No patients died during hospitalization. The median follow-up was 76 months (range, 10ââ?¬â??165\nmonths). One-year, 3-year and 5-year survival for standard resection versus multivisceral resection was 83, 50, and\n56 % versus 83, 66, and 50, respectively. Twelve patients died after a median of 26 months (range, 5ââ?¬â??55 months).\nConclusions: A surgical approach with curative intent is justified in select patients suffering from metastases to\nthe pancreas and offers good long-term survival. The resection of pancreatic metastases of different tumor types\nwas associated with favorable morbidity and mortality when compared with resection of the primary pancreatic\nmalignancies. Our findings also demonstrated that multivisceral resection was feasible, with acceptable long term\noutcomes, even though morbidity rates tended to be higher after multivisceral resection than after standard resection.
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