Background: Laparoscopic splenectomy (LS) is regarded as a second-line treatment for medically refractory\nidiopathic thrombocytopenic purpura (ITP), but the predictive factors for the long-term postoperative responses to\nITP are still a matter of debate. We aimed to investigate the factors that can predict the long-term response after LS\nfor Chinese patients with medically refractory ITP.\nMethods: From January 2011 to September 2016, 78 Chinese patients with ITP who underwent LS were\nretrospectively analyzed. Twelve parameters were analyzed by univariate and multivariate methods.\nResults: Univariate analysis revealed that platelet count on preoperative day (PRD) 1 (P < 0.001) and operative time\n(P = 0.011) were significantly associated with long-term response of ITP after LS. Multivariate analysis revealed that\nplatelet count on PRD 1 was a predictive factor of long-term response (P < 0.001). Furthermore, a long-term, stable\nresponse of platelet count on PRD 1 of > 30.0 � 109/L was easier to achieve than a platelet count on PRD���
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