Aim: To investigative the efficacy of carbon nanoparticles (CNs) to identify\nthe lymph nodes during radical surgery in colorectal cancer. Method: The\nMEDLINE, EMBASE and Cochrane Library databases were searched electronically\nto identify the studies that compared the use of CNs (CN group)\nwith control group in patients undergoing colorectal cancer radical surgery\n(from January 2009 to November 2018). The primary outcome was the number\nof retrieved central lymph nodes. Results: This meta-analysis identified 2\nrandomized controlled trials and 5 non-randomized controlled trials. Compared\nwith the control group, the CN group resulted in an average of 7.16\nmore lymph nodes removed per patient (WMD = 7.16, 95% CI = 3.76 to\n10.57, p < 0.01), 7.26 minutes less required for retrieving lymph nodes (WMD\n=-7.26, 95% CI =-13.43 to-1.09, p = 0.02), and 15.1 ml less blood loss \nduring operation (WMD =-15.11, 95% CI =-23.15 to-7.06, p < 0.01). Although\nthere was no significant difference in the metastatic lymph nodes between\nthe two groups (OR = 1.02, 95% CI = 0.79 to 1.31, p = 0.87), there was\n1.45 times more metastatic lymph of the stained nodes in CN group than in\nthe control group (OR = 1.45, 95% CI = 1.13 to 1.85, p < 0.01). In addition,\nlymph nodes less than 5 mm were detected significantly more in the CN\ngroup than in the control group (OR = 2.15, 95% CI = 1.77 to 2.63, p < 0.01).\nConclusions: The technique of CNs labeled lymph node staining in curative\ncolorectal carcinoma is easy and effective, which can improve the retrieved\nnumber of lymph nodes, especially for nodes < 5 mm. The black stained\nlymph node indicates higher risk of metastasis. Further high quality RCT is\nneeded to verify these conclusions.
Loading....